@mcq_medclub on Instagram: "Correct Answer is Hirschsprung disease 🧠 Explanation: The key clue here is absence of ganglion cells in the rectum. Hirschsprung disease occurs due to failure of neural crest cell migration, leading to absence of ganglion cells in: • Auerbach (myenteric) plexus • Meissner (submucosal) plexus Without ganglion cells → no peristalsis in distal colon → functional obstruction. Classic presentation: • Delayed passage of meconium (>48 hours) • Abdominal distension • Bilious