A 3-drug regimen has strong efficacy against highly drug-resistant TB but has high toxicity with a 1200-mg dose of linezolid. A different dose & duration might improve safety and maintain efficacy. New research findings are summarized in a short video. https://nej.md/3CkXcHE | The New England Journal of Medicine

Dr. Abhishek Shukla explained today that tuberculosis treatment involves multiple medicines because the TB bacteria are slow-growing and can easily develop resistance if only one drug is used. To prevent this, treatment is given as a combination therapy, usually including isoniazid, rifampicin, pyrazinamide, and ethambutol in the initial phase. Each medicine targets the bacteria in a different way, ensuring maximum killing of the germs and reducing the risk of drug-resistant TB. He further discu

Dr. Abhishek Shukla explained today that tuberculosis treatment involves multiple medicines because the TB bacteria are slow-growing and can easily develop resistance if only one drug is used. To prevent this, treatment is given as a combination therapy, usually including isoniazid, rifampicin, pyrazinamide, and ethambutol in the initial phase. Each medicine targets the bacteria in a different way, ensuring maximum killing of the germs and reducing the risk of drug-resistant TB. He further discu