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Pain in Your Butt That Shoots Down Your Leg? It Could Be Piriformis Syndrome. Piriformis syndrome occurs when the piriformis muscle, located deep in your buttock, becomes tight, irritated, or overloaded and places pressure on the nearby sciatic nerve. This can lead to pain, tingling, or numbness that travels from the buttock down the back of the thigh. Common signs and symptoms include: ✅ Deep pain in the buttock ✅ Pain or tingling that may radiate down the back of the leg ✅ Pain with prolonged
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