Leqembi - ALZFORUM
Overview. Name: Leqembi Synonyms: Lecanemab-irmb, BAN2401, mAb158 Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Approved) Company: BioArctic AB, Biogen, Eisai Co., Ltd. Background. BAN2401 is the humanized IgG1 version of the mouse monoclonal antibody mAb158, which selectively binds to large, soluble ...
‘MGWAS’ Ties Brain Metabolites to Alzheimer’s, Parkinson’s, More
Dec 12, 2024 · Make a Comment. To make a comment you must login or register.. References Mutations Citations. APOE C130R (ApoE4) Paper Citations. Chen Y, Lu T, Pettersson-Kymmer U, Stewart ID, Butler-Laporte G, Nakanishi T, Cerani A, Liang KY, Yoshiji S, Willett JD, Su CY, Raina P, Greenwood CM, Farjoun Y, Forgetta V, Langenberg C, Zhou S, Ohlsson C, Richards JB.
Fast Plaque Clearance with Little ARIA? So Teases ... - ALZFORUM
15 Mar 2024. A record 4,700 people from 70 countries attended the 18th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 5 to 9 in Lisbon, Portugal.
ALZFORUM | NETWORKING FOR A CURE
Jan 18, 2025 · Mutations that slow SORL1 trafficking through the cell associate with AD, and recent work helps unveil the mechanisms involved. In neurons, SORL1 deficiency hobbles endosomal network, compromising recycling of proteins such as APP and synaptic receptors.
Remembering Bruce Albala, 70, Leader in BACE Inhibitor …
08 Nov 2024. Scientists in industry and academia were shocked and saddened to hear of the sudden passing of Bruce Albala. Albala died in Greece on October 16 while celebrating his 40th wedding anniversary with his wife.
Can Anna Karenina Help Scientists Find Proteins That Cause …
20 Dec 2024. Many genes and proteins have been linked to Alzheimer’s, but which ones directly contribute to disease? This question has been hard to answer.
‘Proteogenomics’ Ties Genes That Control 38 Proteins to Alzheimer’s
Dec 11, 2024 · “This is a tour de force paper from the Cruchaga team, with impressive scope in terms of both the number of protein aptamers tested and the sample size,” wrote Niklas Mattsson-Carlgren of Lund University in Sweden, who was not involved in the study. Aptamers are short, single-stranded nucleic acids that each fold and bind …
What’s Inside Those Mysterious Biondi Bodies? Hello, TMEM106B!
26 Nov 2024. Cryo-EM has solved yet another molecular riddle. In the September 6 Acta Neuropathologica, scientists led by Bernardino Ghetti, Indiana University School of Medicine, Indianapolis, reported that Biondi bodies—protein inclusions in ependymal cells of the central nervous system—comprise fibrils of none other than TMEM106b.
SIRT6 Reported to Destabilize APP | ALZFORUM
19 Dec 2024. Why is age the strongest risk factor for Alzheimer’s disease? In the December 10 Science Signaling, scientists led by Ning Bai, Difei Wang, Yu Di, and Liu Cao at China Medical University in Shenyang, and Hua Liu at Jinzhou Medical University, offer a clue.
Solanezumab - ALZFORUM
Overview. Name: Solanezumab Synonyms: LY2062430 Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Discontinued) Company: Eli Lilly & Co. Approved for: None Background. Solanezumab is a humanized monoclonal IgG1 antibody directed against the mid-domain of the Aβ peptide. It recognizes soluble monomeric ...