Multiple sclerosis: Pathology, diagnosis and treatments - PMC
The underlying pathophysiology hallmarks are inflammatory lesions that result in neuronal demyelination, axonal damage and subsequent neurological dysfunctions following the formation of …
Pathophysiology | Multiple Sclerosis - U.OSU
Once the inflammatory complement cascade is activated, it causes additional release of cytokines and chemokines, recruitment of inflammatory cells including T cells, monocytes, and B cells. The B cells …
Pathophysiology of multiple sclerosis - Wikipedia
Multiple sclerosis is an inflammatory demyelinating disease of the CNS in which activated immune cells invade the central nervous system and cause inflammation, neurodegeneration, and tissue damage. …
Multiple sclerosis - Symptoms and causes - Mayo Clinic
Nov 1, 2024 · Multiple sclerosis is a disorder in which the body's immune system attacks the protective covering of the nerve cells in the brain, optic nerve and spinal cord, called the myelin sheath. And …
Multiple Sclerosis (MS) - Neurologic Disorders - MSD Manual ...
Aug 22, 2024 · Multiple Sclerosis (MS) - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.
Multiple sclerosis pathophysiology: a comprehensive review of …
Nov 8, 2025 · We detail the dysregulation of both T-cells (Th1 and Th17 subsets) and B-cells in the autoimmune attack on myelin, as well as the intricate mechanisms of neurodegeneration, axonal …
Pathophysiology | Multiple Sclerosis | Clinical Guidance - Healio
Oct 16, 2025 · The pathophysiology of multiple sclerosis (MS) is believed to be immune-mediated, with the adaptive immune system (both T and B cells) responsible for the formation of lesions (also …
A review of multiple sclerosis: From pathophysiology to latest ...
Oct 31, 2025 · Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration within the central nervous system (CNS). It predominantly …
A review on multiple sclerosis: Unravelling the complexities of ...
Feb 16, 2025 · Multiple sclerosis (MS) is a chronic, inflammatory demyelinating disorder of the central nervous system (CNS) targeting myelinated axons. Pathogenesis of MS entails an intricate genetic, …
The neuropathobiology of multiple sclerosis - Nature
May 24, 2024 · In this Review, we provide a neuron-centric overview of recent advances in deciphering neuronal response patterns that drive the pathology of MS.