ALZFORUM | NETWORKING FOR A CURE
4 days ago · Could treating Alzheimer’s disease be as simple as inhaling xenon? Data from mice support this provocative idea. Huffing xenon for 40 minutes weekly shifted microglia from pro-inflammatory to phagocytic, allowing these immune cells to better corral plaques and prevent neurite degeneration.
Leqembi - ALZFORUM
Overview. Name: Leqembi Synonyms: Lecanemab-irmb, BAN2401, mAb158 Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Approved) Company: BioArctic AB, Biogen, Eisai Co., Ltd. Background. BAN2401 is the humanized IgG1 version of the mouse monoclonal antibody mAb158, which selectively binds to large, soluble ...
HMTM | ALZFORUM
Last Updated: 10 May 2024. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.. References News Citations. Tau Inhibitor Fails Again—Subgroup Analysis Irks Clinicians at CTAD 16 Dec 2016; In First Phase 3 Trial, the Tau Drug LMTM Did Not Work.
Memantine - ALZFORUM
Oct 9, 2023 · Papers. Gauthier S, Molinuevo JL.Benefits of combined cholinesterase inhibitor and memantine treatment in moderate-severe Alzheimer's disease. Alzheimers Dement. 2012 Oct 27; PubMed.; Hyde C, Peters J, Bond M, Rogers G, Hoyle M, Anderson R, Jeffreys M, Davis S, Thokala P, Moxham T.
Donepezil - ALZFORUM
May 16, 2023 · Overview. Name: Donepezil Synonyms: Aricept™, Donepezil hydrochloride, Eranz®, E 2020 Chemical Name: 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one Therapy Type: Small Molecule Target Type: Cholinergic System Condition(s): Alzheimer's Disease, Dementia with Lewy Bodies, Down's Syndrome, Parkinson's Disease Dementia U.S. FDA Status: Alzheimer's Disease (Approved ...
Latozinemab - ALZFORUM
Jul 10, 2024 · Overview. Name: Latozinemab Synonyms: AL001, GSK4527223 Therapy Type: Immunotherapy (passive) Target Type: Other Condition(s): Frontotemporal Dementia, Amyotrophic Lateral Sclerosis U.S. FDA Status: Frontotemporal Dementia (Phase 3), Amyotrophic Lateral Sclerosis (Inactive) Company: Alector, GlaxoSmithKline (GSK) Background. AL001 is a recombinant human anti-human sortilin (SORT1) monoclonal ...
Trontinemab - ALZFORUM
Overview. Name: Trontinemab Synonyms: RO7126209, RG6102 , Brain shuttle gantenerumab Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Phase 1/2) Company: Hoffmann-La Roche Background. RO7126209 is a new version of the anti-amyloid monoclonal antibody gantenerumab, engineered to more easily cross the blood ...
Aduhelm - ALZFORUM
Jan 3, 2016 · Overview. Name: Aduhelm Synonyms: Aducanumab, BIIB037 Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Approved) Company: Biogen, Neurimmune Background. BIIB037 is a high-affinity, fully human IgG1 monoclonal antibody against a conformational epitope found on Aβ. It was originally derived by the biotech ...
LY3884961 - ALZFORUM
Overview. Name: LY3884961 Synonyms: PR001, PR001A Therapy Type: DNA/RNA-based Target Type: Other Condition(s): Parkinson's Disease U.S. FDA Status: Parkinson's Disease (Phase 1/2) Company: Eli Lilly & Co., Prevail Therapeutics Background. PR001 is a gene-replacement therapy that uses adeno-associated virus 9 (AAV9) to deliver a functional copy of the GBA1 gene to the brain.
Databases - ALZFORUM
AlzAntibodies. This database aims to provide detailed descriptions of selected antibodies related to the study of Alzheimer’s disease. AlzBiomarker