Premature termination of transcription influences ribosomal RNA output and RNA polymerase I drug sensitivity, revealing a mechanism of resistance to transcription-targeting chemotherapy.

A comprehensive single-cell atlas of AML uncovers regulatory networks and age-dependent molecular differences to advance the understanding of disease mechanisms and enable subtype-specific therapeutic ...

An efficient neural screening approach rapidly identifies circuit modules governing distinct behavioral transitions in response to pathogen exposure.

Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.

Comprehensive residue-level mapping of amyloid-beta recognition reveals how sequence variants, post-translational ...

Mouse primary motor and somatosensory cortices contain detailed information about the many time-varying arm and paw joint ...

Muscle stem cells repurpose the tenogenic factor Scx to establish a muscle-specific transcriptional program that sustains stem cell expansion, migration, differentiation, fusion, self-renewal, and ...

Experiments mapping individual neurons in the sensorimotor cortex of mice show that sharp transitions in functional properties can define cortical regions.

Mir195 enables Ebf1-deficient hematopoietic progenitor cells to mature into B cells, suggesting some miRNA can substitute for transcription factors in differentiation.

Upregulated expression of transcription factors promoting cone identity in late-stage retinal progenitors drives development ...

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

Using a similar unilateral discrimination protocol across three experiments with human adults (n = 96; 1,295 sessions), we now reveal distinct patterns of specificity, generalization, and persistence ...