ISM001-055 was shown to have attenuated cellular senescence through the suppression of various aging processes, thus showing potential as a senomorphic drug.

The key to reversing cellular aging may lie in a protein responsible for toggling cells between a "young" and an "old" state.

AP2A1 could serve as a biomarker for aging and a target for therapies aimed at slowing down or even reversing the aging ...

A groundbreaking study led by researchers at Insilico Medicine has revealed the potential of TNIK inhibition as an innovative ...

Our recent work indicates that cellular senescence is a major factor driving expression of IL-1α in vitro and in vivo . A similar relationship holds for epithelial derived IL-8 and stromal FGF2. Thus ...

Senescent cells stop dividing but don’t die, and cellular senescence has been implicated in the development of a wide range of chronic diseases and disease processes, including obesity ...

The Senescence Accelerated Mouse-Prone 8 (SAMP8) is a naturally occuring mouse line that displays a phenotype of accelerated aging. While maintaining an inbred AKR/J line in the early 1970's, ...

Topical ABT-263 effectively reduced several senescence markers in aged skin, preparing it for improved wound healing.

A groundbreaking study led by researchers at Insilico Medicine has revealed the potential of TNIK inhibition as an innovative anti-aging strategy ...