Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By ...

At the surface, the immune response to a flu virus is simple. Some cells recognize the pathogen and send a signal to the ...

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental ...

Scientists have discovered how a key protein helps maintain strong connections between brain cells that are crucial for ...

It is of great significance to understand the organization and function of the biological system by identifying function modules in protein-protein interaction (PPI) networks. One of important ...

Scientists have uncovered how a protein helps build and maintain vital brain connections, providing insights into the ...

How to use computational methods to effectively predict the function of proteins remains a challenge. Most prediction methods based on single species or single data source have some limitations: the ...

Covalent probes integrated with chemical proteomics have been an efficient method for disclosing new druggable targets and E3 ubiquitin ligases supporting targeted protein degradation. However, a ...

Protein–protein interactions are no longer considered undruggable because of the conceptual and technical advances that allow inhibitors to be generated using rational design principles and ...