TMC207 inhibits the proton pump of mycobacterial ATP synthase, a critical enzyme in the synthesis of ATP for Mycobacterium tuberculosis. Resistance is achieved through mutations at position 63 or ...

Enzyme kinetic data from the BRENDA database were mapped onto the genome-scale metabolic model of Saccharomyces cerevisiae to ...

28 Other workers have suggested that ATP sensitive potassium channels may be a good target following studies in which openers of these channels (pinacidil and cromakalim) reduced citric acid induced ...