Conditional genetics and single-embryo RNA-seq show that SETDB1 extinguishes the transient, retroelement-driven transcriptional programs of the totipotent two-cell state to facilitate the exit from ...

Biologically plausible learning mechanisms have implications for understanding brain functions and engineering intelligent systems. Inspired by the multi-scale recurrent connectivity in the brain, we ...

This valuable study presents a technically sophisticated intravital two-photon calcium imaging approach to characterize Ca²⁺ dynamics in distinct populations of meningeal macrophages in awake, freely ...

Comprehensive residue-level mapping of amyloid-beta recognition reveals how sequence variants, post-translational modifications, and aggregation state shape antibody specificity, thereby guiding ...

Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.

Mir195 enables Ebf1-deficient hematopoietic progenitor cells to mature into B cells, suggesting some miRNA can substitute for transcription factors in differentiation.

Experiments mapping individual neurons in the sensorimotor cortex of mice show that sharp transitions in functional properties can define cortical regions.

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

Using a similar unilateral discrimination protocol across three experiments with human adults (n = 96; 1,295 sessions), we now reveal distinct patterns of specificity, generalization, and persistence ...

A comprehensive single-cell atlas of AML uncovers regulatory networks and age-dependent molecular differences to advance the understanding of disease mechanisms and enable subtype-specific therapeutic ...

Mouse primary motor and somatosensory cortices contain detailed information about the many time-varying arm and paw joint angles during reaching and grasping, implying a 'low-level' role in ...

Muscle stem cells repurpose the tenogenic factor Scx to establish a muscle-specific transcriptional program that sustains stem cell expansion, migration, differentiation, fusion, self-renewal, and ...