Mammalian transmissible spongiform encephalopathy (prion) and amyloid diseases seem to involve the self-propagation of abnormal fibrillar or sub-fibrillar protein aggregates. Similar processes explain ...

Prions -- are they viruses, nucleic acids, or "infectious" proteins? This question has haunted the medical and research community for decades, and it still puzzles investigators who are trying to ...

Transmissible spongiform encephalopathies (TSEs), or prion diseases, are a family of rare progressive, neurodegenerative illnesses that affect both humans and animals. TSE surveillance is important ...

Scientists have determined how a normal protein can be converted into a prion, an infectious agent that causes fatal brain diseases in humans and mammals. The finding, in mice, is expected to advance ...

European Commission which issued a guidance on minimizing the risk of transmitting animal spongiform encephalopathy agents via human and veterinary medicinal products (EMA/410/01 rev.3) (2011/C 73/01) ...

The transmissible spongiform encephalopathies (TSEs) represent an emerging group of diseases that have been labeled as "prion diseases" because of the recent characterization of the infectious agent.

A European Union summary report on the monitoring of transmissible spongiform encephalopathies (TSEs) has been published by the European Food Safety Authority. TSEs are a group of diseases that affect ...

Figure 2: EDRF expression in blood and bone marrow of experimentally induced and natural cases of TSEs. Figure 3: Assignment of EDRF expression to hematopoietic cells committed to the erythroid ...

Transmissible spongiform encephalopathy or prion disease is triggered by the conversion from cellular prion protein to pathogenic prion protein. Notably, C-transmembrane form of prion protein and ...

Agents of transmissible spongiform encephalopathies (TSEs) usually enter the body via a peripheral route and replicate in lymphoreticular tissues before moving into the brain. Any impairment of the ...

Among the animal spongiform encephalopathies -- scrapies, transmissible mink encephalopathy, and bovine spongiform encephalopathy (BSE) -- BSE is certainly the disease that has wreaked the most havoc ...