Self-labeling protein tags such as SNAP-tag offer the opportunity to attach bright and photostable synthetic fluorophores to ...

At the surface, the immune response to a flu virus is simple. Some cells recognize the pathogen and send a signal to the ...

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental ...

Studying proteins in their live cellular context is essential for understanding biological function. Genetically encoded tags, including fluorescent proteins and epitope sequences, are widely used ...

Bacterial single-stranded (ss) DNA-binding proteins (SSBs) facilitate DNA replication, recombination, and repair processes in part by recruiting diverse genome maintenance enzymes to ssDNA. This ...

Single-stranded DNA binding proteins (SSBs) represent one important type of nucleic acid binding proteins and are crucial for many cellular functions, such as DNA replication, transcriptional ...

The biological needs of plants and animals affect their cells' protein content, but the story goes deeper than that.

More specifically, the unknown 3D shapes were paired with known protein functions based on viral shape similarities. Researchers also discovered a mechanism by which viral proteins evade the immune ...

However, the structural mechanisms underlying these interactions are not fully understood. DNA binding proteins can be classified into double-stranded DNA binding proteins (DSBs) and single-stranded ...

Scientists are also trying to determine how other, less-understood proteins function, so as to develop more targeted solutions. One example is fibrillin, which gives skin youthful bounce, says ...

Surprisingly, for Rep, this specificity is altered in the presence of stoichiometric amounts of a single-strand DNA-binding protein (SSB) relative to a fork with a gap in the nascent lagging strand.

One protein that participates in NHEJ and V (D)J recombination, and whose function is still largely unknown, is Pso2p/Artemis, which belongs to the metallo-ß-lactamase associated CPSF Artemis ...