Researchers discover short form of a tumor-produced protein activates natural killer cells
A group of scientists in China has revealed a novel mechanism whereby a short form of IL-18, generated by caspase-3 cleavage ...
Medscape3d
Rivaroxaban for Stroke Prevention in Atrial Fibrillation
Half of renally-cleared rivaroxaban is cleared as unchanged drug and half as inactive metabolites. ‡Potent inhibitors of both CYP3A4 and P-gp include azole antifungals (e.g., ketoconazole ...
Medscape6d
Pharmacogenetics and Irinotecan Therapy
Am J Health Syst Pharm. 2006;63(22):2211-2217. The high rates of toxicity are troubling because toxicity can lead to dehydration, infection, patient discomfort, additional medication requirements ...
Frontiers4d
Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity
In addition to essential physiological functions, BAs and their metabolites are also involved in the differentiation and functions of innate and adaptive immune cells such as macrophages (Macs), ...
gut.bmj4d
Integrated metagenomic and metabolomic analysis reveals distinctive stage-specific gut-microbiome-derived metabolites in intracranial aneurysms
Objective Our study aimed to explore the influence of gut microbiota and their metabolites on intracranial aneurysms (IA) progression and pinpoint-related metabolic biomarkers derived from the gut ...
Frontiers4d
Elevated gut microbiota metabolite bile acids confer protective effects on clinical prognosis in ischemic stroke patients
However, the relationship between gut microbial metabolites, specifically bile acids (BAs), and post-ischemic stroke disability and poor functional outcomes remains unexplored. Methods: Patients with ...