Serine proteases of the lectin pathway. MASPs, a new member of the serine-protease superfamily, are proteolytic enzymes that are responsible for activation of the lectin pathway 38,39,40,41.

Three pathways have now been described in the complement system — the classic, alternative and lectin. A fourth, lytic pathway is added by some authors for membrane attack complex.

Omeros’ OMS721 is a human monoclonal antibody that inhibits MASP-2, which is the effector enzyme of the lectin pathway of the complement system. Omeros controls the worldwide rights to MASP-2 ...