Strong global consensus on measurement and role of ammonia in Hepatic Encephalopathy (HE) Phase 2a results of YAQ007 (oral OPA) show ammonia reduction Utility of rifaximin in HE defined more narrowly ...

Primary biliary cholangitis (PBC) is a chronic cholestatic disorder in which symptoms exert a direct influence on patients’ quality of life. Beyond pruritus and fatigue, patients with PBC are also ...

IgA nephropathy, first described in 1968 by Berger and Hinglais, 1 is the most common form of primary glomerulonephritis. For decades, IgA nephropathy was considered to have a relatively good ...

Hepatic encephalopathy (HE) is a condition that can affect the brain in people who have chronic liver disease. It happens when a damaged liver cannot effectively filter ammonia and other toxins out of ...

Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with obesity, type 2 diabetes (T2DM), and metabolic ...

Transjugular intrahepatic portosystemic shunt (TIPS) is an important intervention for relieving portal hypertension-related complications in patients with decompensated cirrhosis. However, ...

A rare but often fatal complication of the flu is on the rise among young children. A new study warns that cases of acute necrotizing encephalopathy (ANE) – which causes severe brain swelling – are ...

Acquired SEPS are associated with portal hypertension, cirrhosis, and complications of decompensation. In particular, the effects of NVEPS on portal pressure are variable, but there is evidence of ...

In patients with cirrhosis who received a transjugular intrahepatic portosystemic shunt, advanced age was associated with a higher rate of mortality and hepatic encephalopathy 1 year after the ...

Clinical question: Do serum ammonia levels correlate with the severity of overt hepatic encephalopathy (OHE) in hospitalized patients with cirrhosis? Background: Guidelines recommend diagnosing OHE ...