TMC207 inhibits the proton pump of mycobacterial ATP synthase, a critical enzyme in the synthesis of ATP for Mycobacterium tuberculosis. Resistance is achieved through mutations at position 63 or ...

Enzyme kinetic data from the BRENDA database were mapped onto the genome-scale metabolic model of Saccharomyces cerevisiae to ...

which certainly lacked such sophisticated protein machinery as the ATP synthase. There are a few possible abiotic mechanisms, presently under scrutiny in Russell's lab and elsewhere. But ...

Its deletion impairs branched-chain amino acids (BCAA) catabolism, disrupting lipoic acid-dependent enzymes such as pyruvate dehydrogenase (PDH). This deleterious phenotype can be rescued by ...

This research uncovers a groundbreaking link between electron spin and proton transport in biological environment, using lysozyme as a model system. Proton transfer, vital in many life processes, is ...

This is an important textbook for undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine. Written by a team of leading scientists in the field, it ...

This fundamental study advances our understanding of the role that energy metabolism, specifically anaerobic glycolysis, plays during retinal development. Convincing in vitro genetic and ...

28 Other workers have suggested that ATP sensitive potassium channels may be a good target following studies in which openers of these channels (pinacidil and cromakalim) reduced citric acid induced ...

For instance, research indicates that hydroxyoxidase 1 (HAO1), the rate-limiting enzyme for oxalate synthesis, is significantly upregulated in mouse alveolar epithelial cells harboring metastatic ...

1 The First Clinical Medical College, Guangdong Medical University, Zhanjiang, China 2 Department of Obstetrics and Gynecology, Dongguan People’s Hospital, Dongguan, China Ovarian cancer, a ...