Researchers analyze 2.2 million genomes to show that addiction risk is primarily driven by broad genes affecting brain wiring and impulse control, not drug-specific traits.

Most of the genetic risk for developing a substance use disorder comes from genes that broadly affect how our brains process ...

Tobacco-related disorders include tobacco use disorder and tobacco withdrawal. Tobacco and tobacco-based products contain many harmful substances, including nicotine, a highly addictive chemical that ...

Variants in a nicotine receptor gene are associated with a lower likelihood of heavy smoking, according to a study published in Nature Communications. The findings are based on data from populations ...

Cannabis compounds may reduce symptoms for some disorders, but evidence quality is low ...

There was some evidence that cannabinoids can reduce symptoms of cannabis use disorder, insomnia, tic or Tourette's syndrome, and autism spectrum disorder, but the quality of this evidence was ...

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Psychedelic therapy is a promising approach for tackling tobacco addiction, early results of a pilot clinical trial show in which psilocybin outperformed nicotine patches in helping smokers quit.