Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In this ...

A large-scale genomic study by researchers at Central South University and King’s College London reveals that rare and common genetic risks interact antagnistically to maintain healthy telomere length ...

Small plastic or metal bits at the end of shoelaces, known as aglets, prevent laces from unraveling and protect them from wear and tear. Similarly, chromosomes are capped by telomeres—specialized ...

Similar to the way the caps on the ends of a shoelace prevent it from fraying, telomeres—regions of repetitive DNA sequences and a protein structure—protect the tips of chromosomes from damage.