The key to reversing cellular aging may lie in a protein responsible for toggling cells between a "young" and an "old" state.

Our recent work indicates that cellular senescence is a major factor driving expression of IL-1α in vitro and in vivo . A similar relationship holds for epithelial derived IL-8 and stromal FGF2. Thus ...

Senescence is the process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence can be induced by unrepaired DNA damage ...

Senescent cells stop dividing but don’t die, and cellular senescence has been implicated in the development of a wide range of chronic diseases and disease processes, including obesity ...

Senescence is a process where cells cease dividing and undergo distinctive phenotypic changes. Senescence has a key role in the aging process and has also been implicated as a major cause of ...

The Senescence Accelerated Mouse-Prone 8 (SAMP8) is a naturally occuring mouse line that displays a phenotype of accelerated aging. While maintaining an inbred AKR/J line in the early 1970's, ...

Topical ABT-263 effectively reduced several senescence markers in aged skin, preparing it for improved wound healing.

The latest findings on the interaction between cell death and cellular senescence in cancer and their pathophysiological significance have been reviewed by a team from Osaka Metropolitan University's ...

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. Oncotarget 10: 8226-43, 2015 Abbas Manji G, Singer S, Koff A, and Schwartz ...

In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...

Senescent cells stop dividing but don’t die, and cellular senescence has been implicated in the development of a wide range of chronic diseases and disease processes, including obesity, cancer, aging, ...