Chaperones function in protein folding and ribosome biogenesis. Cells lacking both SSB and NAC accumulated aggregates consisting mostly of ribosomal proteins and pre-ribosomal RNA (rRNA) species.

J-proteins are obligate partners of Hsp70s, forming a ubiquitous class of molecular chaperone machinery. The ribosome-associated Hsp70 of yeast Ssb binds nascent polypeptides as they exit the ...

However, this is no longer the case if the co-chaperone RAC, another ribosome-bound complex that supports the function of Ssb, is absent. Without RAC, abnormal protein folding occurs in Ssb mutant ...

CHAMPAIGN, Ill. — Researchers report that a single-stranded DNA-binding protein (SSB), once thought to be a static player among the many molecules that interact with DNA, actually moves back and ...