(A) Immunofluorescence staining of HCV-core protein in HCV replicating Huh7 cells. (B) FACS analysis of EpCAM and CD44 expression in HCV replicating Huh7 cells. (C) RTD-PCR analysis of HCV-RNAin ...

Present interferon-based therapy for chronic hepatitis C is limited by both efficacy and tolerability. Telaprevir and boceprevir are the first two direct-acting antiviral drugs (DAAs) that inhibit ...

Small Molecule Combination Therapies Are Being Investigated to Increase Response Rates Researchers agree that now is a crucial time to be involved in hepatitis C virus (HCV) research. “Current ...

The GS-441524 Remdesivir metabolite alongside ADP-ribose; HCV drug BOC binding to the NSP5 protease binding pocket. In the search for new ways to use small molecule drugs to prevent and treat Covid-19 ...

Occult HCV and HBV infections are recently identified entities whose existence became evident when nucleic acid amplification assays of enhanced sensitivity were employed for the detection of viral ...

The worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, has stimulated intensive ...

A drug that is already in clinical trials against hepatitis C virus can also prevent hepatitis E virus from replicating.

The research team at Icahn Mount Sinai then tested whether these seven drugs would inhibit SARS-CoV-2 virus replication in monkey and human cells grown in culture. In subsequent experiments the ...