Processive DNA polymerases that replicate chromosomes interact with a ring-shaped clamp that encircles DNA and slides along the duplex. All sliding clamps (Escherichia coli β-clamp, T4 bacteriophage ...

An elusive step in the process of human DNA replication has been observed for the first time, report scientists at Penn State University. The scientists say they’ve discovered how a key step in human ...

An elusive step in the process of human DNA replication has been observed, for the first time, by scientists. The step, which is crucial for DNA replication in humans and other forms of life, had ...

The DNA damage response is essential for maintaining genome integrity. When DNA damage or replication stress occurs, a checkpoint signaling pathway is activated to arrest the cell cycle and initiate ...

According to senior author Stephen J. Benkovic, an Evan Pugh Professor of Chemistry and Holder of the Eberly Family Chair in Chemistry at Penn State, the scientists "discovered how a key step in human ...

Another surprise was that the 9-1-1 clamp loader complex was observed to bind DNA in the opposite orientation from other clamp loader complexes that act on undamaged DNA during normal DNA replication.

DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...