Centromere chromatin is characteristic for the presence of CENP-A, a variant of histone H3. Chromatin composed of CENP-A plays a key role as the site of kinetochore formation and therefore is ...

A genomic study of human and selected nonhuman primate centromeres has revealed their unimaginable diversity and speed of evolutionary change. In cell genetics, a centromere is the spot where two ...

During cell division, the mitotic spindle attaches to chromosomes at centromeric regions to ensure accurate chromosome segregation. In higher eukaryotes, the centromere is defined by the composition ...

If I asked you, dear reader, to come up with a shortlist of the most monumental scientific achievements of the last century, chances are the Human Genome Project (HGP) would appear somewhere on that ...

The centromere of chromosomes plays a crucial role in cell division. Using the model plant Arabidopsis thaliana, an international team of researchers led by the Leibniz Institute IPK has investigated ...

In the cell, chromosomal DNA is wrapped around protein complexes in a structure often described as “beads on a string” (Figure 1). Each bead—called a nucleosome—contains roughly 140 base-pairs (bp) of ...

The study provides significant insights into cucumber centromeres by identifying key centromeric satellite sequences and retrotransposons. Researchers found notable differences in centromeric DNA ...

When people think of DNA, they usually think of genes, the parts that code for proteins and drive inherited traits. But there's a whole lot of DNA beyond genes that we are just starting to understand.

The two proteins KNL2 and CENP-C are crucial for the correct separation of chromosomes during cell division. To dock to the centromere, the newly described additional binding regions (DNA-b) to the ...

Female reproductive health is affected by a number of disorders that can seriously impact quality of life. The X chromosome’s involvement in meiotic drive mechanisms could be a key factor in ...

The centromere of chromosomes plays a crucial role in cell division. Using the model plant Arabidopsis thaliana, an international team of researchers has investigated how two crucial proteins -- KNL2 ...