The dehydrogenase complexes serve as pivotal regulators in cellular metabolism, orchestrating key oxidative reactions within the tricarboxylic acid (TCA) cycle and beyond. These multi‐enzyme ...

Metabolic reprogramming and circadian disruption drive cellular senescence. Discover how repurposing vutiglabridin to target ...

Aging is associated with progressive alterations in endocrine signalling that disrupt the regulation of energy balance and metabolic homeostasis. Changes in ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...

Pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer and has a low five-year survival rate. It begins with a reversible state called acinar-to-ductal metaplasia, where cells ...

Aerobic glycolysis dominates lesion bioenergetics, with lactate promoting histone lactylation, M2 macrophage polarization, ...

This disruption has wide-ranging effects. When SIRT1 is suppressed, the liver shifts toward storing fat instead of burning it ...

Study identifies a specific link between insulin resistance, brain structure, and cognitive impairment in Bipolar Disorder, ...