Break-induced replication (BIR) is a specialised repair pathway activated when only one end of a DNA double-strand break (DSB) can locate homologous sequences elsewhere in the genome. Unlike canonical ...

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break-when both sides of the DNA helix are cut at once. Healthy cells can normally fix ...

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized. Scientists at Scripps Research have discovered ...