Antibody-drug conjugates are rapidly expanding cancer therapies, with 19 approved globally and many more in development, but ...

Researchers have developed a novel antibody-based enzyme switch that converts antibody–antigen binding into enzyme activity, paving the way from detection via bioluminescence to the control of ...

The past decade in oncology has been marked by the rise of immunotherapy, which leverages the immune system to attack tumors. For many solid tumors, immune checkpoint inhibitors have supplanted ...

Among the most promising tools of cancer therapy, engineered immune cells known as chimeric antigen-receptor (CAR) T cells have already transformed the treatment of blood cancers. Yet, despite their ...

Antibody reactome profiling is a powerful approach for analyzing antibody-antigen interactions at scale, offering a comprehensive view of an individual’s immune history and current immune status. This ...

The Single-antigen Bead (SAB) assay has revolutionized the detection of anti-HLA antibodies, which are critical in transplantation medicine. Despite its advantages, several limitations and challenges ...

Chimeric antigen receptor-T (CAR-T) cell therapy represents a major breakthrough in cancer immunotherapy, providing remarkable clinical benefits for ...

Immunoassays are measurement procedures that use immune-based reagents to generate a detectable signal, allowing scientists to quantify biological processes. Scientists perform immunoassays to measure ...

Monoclonal antibodies (mAbs) are manufactured proteins that behave similarly to antibodies found naturally in the body. Researchers initially developed them for treating certain cancers but have now ...

Researchers say they have used a high-sensitivity mass spectrometry technique to improve the accuracy of sandwich ELISA. The team, from biopharmaceutical company Regeneron, hopes their work will help ...