The development and spread of antibiotic resistance represents one of the greatest threats to global health. To overcome these resistances, drugs with novel modes of action are urgently needed.

The Na+-NQR enzyme is vital for energy production in pathogenic bacteria like the one that causes cholera, making it a highly ...

A newly discovered mechanism renders antibiotic-resistant bacteria vulnerable by disabling both their individual resistance and a process known as cross-protection, the ability of resistant bacteria ...

New drug that disrupts two cellular targets would make it much harder for bacteria to evolve resistance. A new antibiotic that works by disrupting two different cellular targets would make it 100 ...

A study analyzing antimicrobial resistance patterns in vaginal swab samples from 2019 to 2022 shows an increasing resistance ...

Superbugs, bacteria that are immune to multiple antibiotics, pose a great challenge to modern medicine. Researchers have now identified a weakness in the bacterial machinery that drives antibiotic ...

Lariocidin hits drug-resistant bacteria where others fail — by hijacking the ribosome at a new site, bypassing defences, and opening the door to a new generation of antibiotics. Lariocidin, a ...

The rise of antimicrobial-resistant pathogens has spurred scientists to search far and wide for new drugs. And while many antimicrobial molecules have been discovered in recent years, it’s rare to ...

Madecassic acid is best known in Korean skincare as a soothing “hero ingredient,” but scientists now believe it could also ...

Using high-resolution cryo-electron microscopy (cryo-em), researchers from Durham University, Jagiellonian University, and the John Innes Centre uncovered unprecedented detail of gyrase’s action on ...